Monitoring the anti-cancer potential of gold nanoparticles under the influence of electroporation and ultra-low electromagnetic field (ULEMF) frequencies relative to time on colon cancer cell-lines (HCT-116) مراقبة القدرة المضادة للسرطان للجزئيات النانوية الذهبية تحت تأثير التثقيب الكهربائي والترددات الكهرومغناطيسية المنخفضة )ULEMF )نسبيا للوقت على خاليا سرطان القولون )HCT-116( \\GP\\DR. Riham Mohsen ( SPRING 2018 ) (Record no. 13914)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02886nam a22002297a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20190306175324.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180719b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | MSA |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.31 |
| Item number | A.A.M 2018 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Alaa Attia Abdelrauof Attia. 152261 |
| 245 ## - TITLE STATEMENT | |
| Title | Monitoring the anti-cancer potential of gold nanoparticles under the influence of electroporation and ultra-low electromagnetic field (ULEMF) frequencies relative to time on colon cancer cell-lines (HCT-116) مراقبة القدرة المضادة للسرطان للجزئيات النانوية الذهبية<br/>تحت تأثير التثقيب الكهربائي والترددات الكهرومغناطيسية<br/>المنخفضة )ULEMF )نسبيا للوقت على خاليا سرطان القولون<br/>)HCT-116( \\GP\\DR. Riham Mohsen ( SPRING 2018 ) |
| Statement of responsibility, etc. | Alaa Attia Abdelrauof Attia. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Giaz : |
| Name of publisher, distributor, etc. | MSA, |
| Date of publication, distribution, etc. | 2018. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 79 p. :, |
| Other physical details | 26 CM. |
| 440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE | |
| Title | Biotechnology DISTINGUISHED PROJECTS 2018 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The use of nanotechnology in cancer therapy is based on<br/>the usage of molecules that can affect cancerous cells as<br/>well as mitochondrial membrane in order to induce cancer cell programmed death.<br/>This method has shown overwhelming effects; hence the target of this project is<br/>to evaluate the role of gold nanoparticles’ anti-cancer potential under the effect of<br/>electroporation, in addition to the effect of ultra-low electromagnetic field (ULEMF)<br/>frequencies on HCT 116 colon cancer cell line. It was noticed that this method of<br/>using ULEMF displayed a higher potential of anti-cancer activity than the use of<br/>gold nanoparticles used single handed (engulfed endocytosis). At the same time<br/>cell apoptosis that is accompanied with high percentage of cell arrest in case of<br/>treatment with electroporation, gold nanoparticles as well as electromagnetic field<br/>of 50 mT for 30 mins showed the best results in comparison with other treatments.<br/>Also, it has been signified that the usage of these treatment combinations resulted<br/>in a highly elevated gene expression of pro-apoptotic genes (P53, Bax) and down<br/>regulation of anti-apoptotic gene (Bcl-2). It was also noticed that an arrest of cells<br/>occurred at the G2/M phase compared to other treatment regimes. Data recorded<br/>revealed that the use of gold nanoparticles, electroporation and electromagnetic<br/>field in a dose dependent manner can increase apoptosis and necrosis [200v]- [25<br/>mT— 50 mT]. It can be suggested that the use of electromagnetic field as well as,<br/>gold nanoparticles and electroporation can be a promising tool for cancer |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | anti-cancer potential of gold . |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | (ULEMF). |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aly Fahmy. |
| Relator term | External Supervisor |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1FYIWXQdRaHA00t9pt2yjJse9Y-XJtROF/view?usp=sharing">https://drive.google.com/file/d/1FYIWXQdRaHA00t9pt2yjJse9Y-XJtROF/view?usp=sharing</a> |
| Public note | FULL TEXT PRESS HERE |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Gradution Project |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | Centeral Library | Centeral Library | Soft Copy located on library Cataloge | 19.07.2018 | GP373BIO2018 | 81845 | 19.07.2018 | 19.07.2018 | Distinguished Graduation Projects |