The investigation of antiviral mechanisms of chitosan nanoparticles encapsulating curcumin against Hepatitis C Virus genotype – 4a on human hepatoma cell lines اآلليات المضادة للفيروسات من جسيمات ال Chitosan النانوية المغلفة بالكركمين ضد النمط الجيني لفيروس االلتهاب الكبدي سي - 4 أ في خالياالكبدالبشرية \\GP\\Dr. Hossam Taha. ( SPRING 2018 ) (Record no. 13923)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02714nam a22002417a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20190307085557.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180719b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | MSA |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.71 |
| Item number | A.A.I 2018 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Aya Ali Mohamed. 150423 |
| 245 ## - TITLE STATEMENT | |
| Title | The investigation of antiviral mechanisms of chitosan nanoparticles encapsulating curcumin against Hepatitis C Virus genotype – 4a on human hepatoma cell lines اآلليات المضادة للفيروسات من جسيمات ال Chitosan النانوية<br/>المغلفة بالكركمين ضد النمط الجيني لفيروس االلتهاب الكبدي سي<br/>- 4 أ في خالياالكبدالبشرية \\GP\\Dr. Hossam Taha. ( SPRING 2018 ) |
| Statement of responsibility, etc. | Aya Ali Mohamed. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Giza: |
| Name of publisher, distributor, etc. | MSA University, |
| Date of publication, distribution, etc. | 2018. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 130 P. :, |
| Other physical details | 26 CM. |
| 440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE | |
| Title | BIOTECHNOLOGY DISTINGUISHED PROJECTS 2018 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Current double and triple treatments with direct acting antivirals (DAAs) were<br/>recently reported to cause several side effects and thereby effective, less toxic<br/>antiviral agents are still needed. Accordingly, this study aimed at investigating the<br/>role of some natural and synthetic antivirals; curcumin, chitosan nanoparticles<br/>(CSNPs) and chitosan encapsulating curcumin nanocomposite on HCV-G4<br/>replication in Huh7.5 cells. Viral Replication was quantified in HCV/G4 infected<br/>Huh7.5 cells either treated or not with curcumin, chitosan nanoparticles (CSNPs)<br/>and chitosan encapsulating curcumin nanocomposite using quantitative real time<br/>PCR assay. Nanocomposite (chitosan nanoparticles encapsulating curcumin) was<br/>successfully prepared and controlled to the size of 15 nm and charges of 25 mV,<br/>characterized by TEM, XRD, FTIR. Curcumin was encapsulated at concentration of<br/>42mg/gm of chitosan nanoparticles. Chitosan nanoparticles at concentration of<br/>100μg/mL showed almost 100% reduction of viral replication whereas the non-toxic<br/>dose of curcumin (13 μm) showed 50% reduction in the viral initial titer as detected<br/>by real-time PCR assay. Combining both agents in the nanocomposite led to a higher<br/>reduction in viral replication. Nanocomposite showed a significant reduction in viral<br/>replication when compared to curcumin and chitosan alone which suggests the<br/>potential role of nanocomposite as a novel, safe and effective antiviral agent.<br/>Keywords: curcumin, chitosan, nanocomposite, HCV – 4. |
| 630 ## - SUBJECT ADDED ENTRY--UNIFORM TITLE | |
| Form subdivision | Medical Biotechnology |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | antiviral mechanisms. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Hepatitis C. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samah Loutfy. |
| Relator term | External Supervisor |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1ferD8oFQTYASOVFbG2JNrYKbA-XeCj1G/view?usp=sharing">https://drive.google.com/file/d/1ferD8oFQTYASOVFbG2JNrYKbA-XeCj1G/view?usp=sharing</a> |
| Public note | FULL TEXT PRESS HERE |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Gradution Project |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | Centeral Library | Centeral Library | Soft Copy located on library Cataloge | 19.07.2018 | GP376BIO2018 | 81846 | 19.07.2018 | 19.07.2018 | Distinguished Graduation Projects |