THE EFFECT OF MODULATION OF RNA EXPRESSION ON MYOCARDIAL INFARCTION RSPHO8.2 // GP // Dr. Mai Amin Zaafan (2018 - 2019) (Record no. 24969)
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| fixed length control field | 02448nam a22002537a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20190728115021.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180715b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | MSA |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.1 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Amr Mohamed Alaa 150557 |
| 245 ## - TITLE STATEMENT | |
| Title | THE EFFECT OF MODULATION OF RNA<br/>EXPRESSION ON MYOCARDIAL INFARCTION RSPHO8.2 // GP // Dr. Mai Amin Zaafan (2018 - 2019) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Giza : |
| Name of publisher, distributor, etc. | MSA, |
| Date of publication, distribution, etc. | 2019. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 29 p. |
| 440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE | |
| Title | PHARMACY DISTINGUISHED PROJECTS 2019 |
| 500 ## - GENERAL NOTE | |
| General note | Pharmacy - Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Myocardial infarction (MI) is myocardial cell death due to severe and prolonged ischemia<br/>produced from atherosclerosis-related coronary artery disease. MI triggers a cascade of events<br/>and reparative phases end with myocardial cell necrosis. MicroRNA (miR) is non-coding single<br/><br/>stranded RNA that regulates protein expression. miR-103 is used to regulate expression of Fas-<br/>associated death domain (FADD) which decreases necroptosis of ischemic myocardium. The<br/><br/>study aims to investigate the modulatory effect of regulating mRNAs translation processes of<br/>myocardial infarction induced with Isoprenaline HCL 100 mg/kg (ISO) by injecting miR-103<br/>inhibitor. Eighteen mice (15-25 gm) were allocated into three groups; Group A (control)<br/>received normal saline, Group B received ISO and Group C received ISO and miR-103<br/>inhibitor. Mice were scarified by cervical dislocation under urethane anesthesia. Blood and<br/>hearts samples were collected for biochemical analysis of miR103, FADD, RIPK, IL-6 and<br/>Troponin-I. In addition, hearts were used for histopathological examination. Results showed<br/>that administration of miR-103 antagomir leads to increase in FADD protein levels in group C<br/>compared to group B. While miR-103, RIPK, and IL-6 showed high levels of expression in<br/>group B that is attenuated in group C. cardiac troponin-I also supported the previous results.<br/>Histopathological test showed normal histological structure in groups A and C while focal<br/>degeneration in myocardium in B. Accordingly, these results indicate a promising suppression<br/>of MI manifestations upon inhibition of miR-103. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Myocardial Infarction |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ayman Selim Ahmed 151497 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bana Ammar AlBarazi 154285 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shahd Yehia AlWais 151775 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1qGSlsIjxJXrGonraH1WNNweQrg7pMvOo/view">https://drive.google.com/file/d/1qGSlsIjxJXrGonraH1WNNweQrg7pMvOo/view</a> |
| Public note | FULL TEXT PRESS HERE |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Distinguished Graduation Projects |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | Centeral Library | Centeral Library | Soft Copy located on library Cataloge | 28.07.2019 | GP68PH2019-COLOGY | 82186 | 28.07.2019 | 28.07.2019 | Distinguished Graduation Projects |