Antihyperglycemic activity evaluation and chemical profiling of the edible pericarps of Phaseolus vulgaris L. // GP // DR. Shahira Mohammed ( 2018 - 2019 ) (Record no. 24990)
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| 000 -LEADER | |
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| fixed length control field | 02800nam a22002417a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20190729115600.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190729b ||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | MSA |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Asmaa Tarek Farouk 151405 |
| 245 ## - TITLE STATEMENT | |
| Title | Antihyperglycemic activity evaluation and chemical profiling of the edible pericarps of Phaseolus vulgaris L. // GP // DR. Shahira Mohammed ( 2018 - 2019 ) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Giza |
| Name of publisher, distributor, etc. | MSA |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 42 P. |
| 440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE | |
| Title | PHARMACY DISTINGUISHED PROJECTS 2019 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The objective of our study is to find a scientific evidence for the traditional use of Phaseolus<br/>vulgaris L. In addition, to evaluate the effect of the combination between the plant extract and<br/>mesenchymal cells on type I diabetes.<br/>The social importance of diabetes mellitus is due to its significant spread in addition to its serious<br/>complications. Medicinal plants derived from different traditional systems are now excessively<br/>investigated for their effectiveness to facilitate the course of diabetes and its complications. One<br/>of such plants is Phaseolus vulgaris L. This plant was used in traditional medicine, for the<br/>treatment of diabetes and its complications.<br/>The in vivo antihyperglycemic effect was evaluated by using the polar and non-polar fractions of<br/>the 95% ethanol extract of the dried powder of P. vulgaris pericarps. In STZ-induced diabetic rats,<br/>the fractions were administered daily for 28 days using the oral route in the dose of 100 and 200<br/>mg/kg b.w. Another experiment was conducted in STZ-diabetic rats in which the non-polar<br/>fraction was tested again at its effective dose 200 mg/kg alone and in combination with<br/>intraperitoneal injection of bone marrow derived mesenchymal cells (1000.000 cells/rat i.p). The<br/>secondary metabolites of both P. vulgaris pods’ fractions the polar and non-polar fractions were<br/>analyzed using LC-MS/MS analysis to have a full picture of their composition.<br/>The non-polar fraction at 200 mg/kg showed the highest activity as it caused maximal reduction<br/>of serum glucose, total cholesterol, total triglycerides, and a significant increase in serum insulin<br/>and high density lipoprotein (HDL). The antidiabetic effect of the non-polar fraction of P. vulgaris<br/>was highly augmented when injected in combination with the mesenchymal cells.<br/>Our work provides a scientific base for the antidiabetic effect of Phaseolus vulgaris L. pericarps<br/>which is mainly attributed to its insulin secretagogue effect. |
| 648 ## - SUBJECT ADDED ENTRY--CHRONOLOGICAL TERM | |
| Chronological term | vulgaris |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bassant Mohamed Hussein 151921 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Doaa Mohammed Mohammed 155287 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ebtehal Saber Rabei 153955 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1gJ04-mszGhAW94hsCigcbkl9Cs98XMGs/view">https://drive.google.com/file/d/1gJ04-mszGhAW94hsCigcbkl9Cs98XMGs/view</a> |
| Public note | FULL TEXT PRESS HERE |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Distinguished Graduation Projects |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | Centeral Library | Centeral Library | Second Floor - Pharmacy | 29.07.2019 | GP68PHCognosy2019 | 82048 | 29.07.2019 | 29.07.2019 | Distinguished Graduation Projects |