000 | 02764nam a22002537a 4500 | ||
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999 |
_c25007 _d25007 |
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003 | OSt | ||
005 | 20190805094053.0 | ||
008 | 190801b ||||| |||| 00| 0 eng d | ||
040 | _cMSa | ||
082 | _a547 | ||
100 | _aAhmed Mohamed 151639 | ||
245 | _aNanoformulation and Pharmacological Evaluation of Antiaging Herbal Product(s) (Nanostructure lipid carrier, NLC) // GP / / Dr. Reham Amer // Dr. Pakinam Zikry (2018 - 2019) | ||
260 |
_aGIZA : _bMSA, _c2019. |
||
300 | _a41 P. | ||
440 | _a PharmaciesDISTINGUISHED PROJECTS 2019 | ||
500 | _aPharmacy - Organic Chemistry | ||
520 | _aSkin aging is a complex of biological process which affected by constant exposure to ultraviolet (UV) irradiation with subsequent generation of reactive oxygen species leading to collagen deficiency and eventually skin wrinkling. Different techniques were reported for treatment; however the application of anti-aging creams is still the best choice among various treatment methods to their nourishing effect. Apart from that herbal formulation has widely demanded in the world market for its safety. In the present study lipid nanoparticles (LNPs) are used in the formulation of anti-aging Citrus Sinensis (CS) cream due to its safety and biocompatibility of its lipid components. Eight different formulations of CS-LNPs were prepared and optimized using 3 full factorial designs. Three factors were evaluated drug concentration (X1), homogenization speed (X2) and nanoparticle type (X3). Different parameters were measured including; zeta potential (ZP), polydispersity index (PDI), particle size, entrapment efficiency (EE %) and skin occlusion test. Morphological study by using scanning electron microscopes (SEM) confirms the nanometric size of the prepared formulations with spherical and smooth surface. It was suggested that the optimized formulation (F7) was found to have (245μm) particle size, (91.065%) Entrapment Efficiency, and (91.385) Occlusive effect. In vitro permeation study of the optimized formulation through synthetic membrane showed prolonged release of medication within 24 hrs. Finally, it can be concluded that the prepared anti-aging CS/NLC cream was safe, convenient, and effective carrier to deliver the herbal medication it also showed better penetration into the skin with a significant anti-aging effect thus it will be a promising product in skin care cosmetics. | ||
650 |
_aNanoformulation and Pharmacological _x(Nanostructure lipid carrier _yAntiaging Herbal Product(s) |
||
700 | _aAsim Reda 151355 | ||
700 | _aManar Tarek 150761 | ||
700 | _aSara Yasser 151317 | ||
856 |
_uhttps://drive.google.com/file/d/1wyhUy9j78z2i0OHpOvKrd7k1dmzM3QAr/view _zFULL TEXT PRESS HERE |
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942 |
_2ddc _cD.GP |